Target cell-directed degradation of perforin mRNA in CTL: lack of correlation with loss of protein and lytic ability.

@article{Bochan1994TargetCD,
  title={Target cell-directed degradation of perforin mRNA in CTL: lack of correlation with loss of protein and lytic ability.},
  author={Markian R. Bochan and Grace Hommel-Berrey and Zacharie Brahmi},
  journal={Molecular immunology},
  year={1994},
  volume={31 5},
  pages={401-10}
}
We have previously shown that CTL and NK cells rapidly down regulate perforin mRNA and become functionally inactive within 4-6 hr after exposure to sensitive target cells (TC). We report here for the first time that CTL also down regulate perforin mRNA upon exposure to resistant, but binding, TC. When three separate human MHC-restricted CTL lines were… CONTINUE READING