Target-cancer-cell-specific activatable fluorescence imaging probes: rational design and in vivo applications.

@article{Kobayashi2011TargetcancercellspecificAF,
  title={Target-cancer-cell-specific activatable fluorescence imaging probes: rational design and in vivo applications.},
  author={Hisataka Kobayashi and Peter L. Choyke},
  journal={Accounts of chemical research},
  year={2011},
  volume={44 2},
  pages={83-90}
}
Conventional imaging methods, such as angiography, computed tomography (CT), magnetic resonance imaging (MRI), and radionuclide imaging, rely on contrast agents (iodine, gadolinium, and radioisotopes, for example) that are "always on." Although these indicators have proven clinically useful, their sensitivity is lacking because of inadequate target-to-background signal ratio. A unique aspect of optical imaging is that fluorescence probes can be designed to be activatable, that is, only "turned… CONTINUE READING
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Activatable optical imaging probes with various fluorophore - quencher combinations

  • M. Ogawa, N. Kosaka, Y. Urano, P. L. Choyke, H. Kobayashi
  • Proc . SPIE
  • 2009

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