Target binding improves relaxivity in aptamer–gadolinium conjugates

Abstract

MRI contrast agents (CA) have been heavily used over the past several decades to enhance the diagnostic value of the obtained images. From a design perspective, two avenues to improve the efficacy of contrast agents are readily evident: optimization of magnetic properties of the CA, and optimization of the pharmacokinetics and distribution of the CA in the… (More)
DOI: 10.1007/s00775-012-0930-z

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