Target-based resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 5463, a novel bacterial type II topoisomerase inhibitor.

@article{Nayar2015TargetbasedRI,
  title={Target-based resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 5463, a novel bacterial type II topoisomerase inhibitor.},
  author={Asha S. Nayar and Thomas J. Dougherty and Folkert Reck and Jason Thresher and Ning Gao and Adam B Shapiro and David E. Ehmann},
  journal={Antimicrobial agents and chemotherapy},
  year={2015},
  volume={59 1},
  pages={331-7}
}
In a previous report (T. J. Dougherty, A. Nayar, J. V. Newman, S. Hopkins, G. G. Stone, M. Johnstone, A. B. Shapiro, M. Cronin, F. Reck, and D. E. Ehmann, Antimicrob Agents Chemother 58:2657-2664, 2014), a novel bacterial type II topoisomerase inhibitor, NBTI 5463, with activity against Gram-negative pathogens was described. First-step resistance mutations… CONTINUE READING