Target antigens for anti-neutrophil cytoplasmic autoantibodies (ANCA) are on the surface of primed and apoptotic but not unstimulated neutrophils.

@article{Yang2000TargetAF,
  title={Target antigens for anti-neutrophil cytoplasmic autoantibodies (ANCA) are on the surface of primed and apoptotic but not unstimulated neutrophils.},
  author={Jia Jin Yang and Russell H. Tuttle and Susan L. Hogan and John G. Taylor and Brian D. Phillips and Ronald J. Falk and John Charles Jennette},
  journal={Clinical and experimental immunology},
  year={2000},
  volume={121 1},
  pages={
          165-72
        }
}
The reaction of ANCA with ANCA antigens on the surface of neutrophils may play a critical role in the pathogenesis of ANCA vasculitis. Therefore, an understanding of the circumstances that result in surface expression of these antigens is important for an understanding of pathogenic mechanisms. In this study we investigated the surface expression of ANCA antigens on quiescent, primed, and apoptotic neutrophils. ANCA antigens and other granule constituents were not detected on the surface of… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 29 CITATIONS