Target antigens determine graft-versus-host disease phenotype.

  title={Target antigens determine graft-versus-host disease phenotype.},
  author={Daniel H Kaplan and Britt E. Anderson and Jennifer Madison McNiff and D Jain and Mark J. Shlomchik and Warren D Shlomchik},
  journal={Journal of immunology},
  volume={173 9},
Chronic graft-vs-host disease (cGVHD) is an increasingly frequent complication of allogeneic stem cell transplantation. Phenotypically, cGVHD differs from patient to patient; in particular, a subset of patients develops extensive cutaneous fibrosis. Similarly, graft-vs-host disease (GVHD) is distinct in inbred murine donor:recipient pairings, indicating a genetic component to disease phenotype. The B10.D2 -->BALB/c (H-2d) strain pairing uniquely recapitulates key pathologic features of fibrotic… CONTINUE READING
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