Target-Selective Protein S-Nitrosylation by Sequence Motif Recognition

  title={Target-Selective Protein S-Nitrosylation by Sequence Motif Recognition},
  author={Jie Jia and Abul Arif and Fulvia Terenzi and Belinda Willard and Edward F Plow and Stanley L. Hazen and Paul L. Fox},
S-nitrosylation is a ubiquitous protein modification emerging as a principal mechanism of nitric oxide (NO)-mediated signal transduction and cell function. S-nitrosylases can use NO synthase (NOS)-derived NO to modify selected cysteines in target proteins. Despite proteomic identification of over a thousand S-nitrosylated proteins, few S-nitrosylases have been identified. Moreover, mechanisms underlying site-selective S-nitrosylation and the potential role of specific sequence motifs remain… CONTINUE READING
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