Target Protectors Reveal Dampening and Balancing of Nodal Agonist and Antagonist by miR-430

  title={Target Protectors Reveal Dampening and Balancing of Nodal Agonist and Antagonist by miR-430},
  author={Wen-Yee Choi and A. Giraldez and A. Schier},
  pages={271 - 274}
  • Wen-Yee Choi, A. Giraldez, A. Schier
  • Published 2007
  • Biology, Medicine
  • Science
  • MicroRNAs (miRNAs) repress hundreds of target messenger RNAs (mRNAs), but the physiological roles of specific miRNA-mRNA interactions remain largely elusive. We report that zebrafish microRNA-430 (miR-430) dampens and balances the expression of the transforming growth factor–β (TGF-β) Nodal agonist squint and the TGF-β Nodal antagonist lefty. To disrupt the interaction of specific miRNA-mRNA pairs, we developed target protector morpholinos complementary to miRNA binding sites in target mRNAs… CONTINUE READING
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