Target Identification of Bioactive Covalently Acting Natural Products.

  title={Target Identification of Bioactive Covalently Acting Natural Products.},
  author={Daniel K. Nomura and Thomas J. Maimone},
  journal={Current topics in microbiology and immunology},
  • D. Nomura, T. Maimone
  • Published 2019
  • Biology, Chemistry
  • Current topics in microbiology and immunology
There are countless natural products that have been isolated from microbes, plants, and other living organisms that have been shown to possess therapeutic activities such as antimicrobial, anticancer, or anti-inflammatory effects. However, developing these bioactive natural products into drugs has remained challenging in part because of their difficulty in isolation, synthesis, mechanistic understanding, and off-target effects. Among the large pool of bioactive natural products lies classes of… 
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