Target Identification: A Challenging Step in Forward Chemical Genetics

  title={Target Identification: A Challenging Step in Forward Chemical Genetics},
  author={R. K. Das and Animesh Samanta and Krishna Kanta Ghosh and Duanting Zhai and Wang Xu and Dongdong Su and Cheryl Leong and Young‐Tae Chang},
  journal={Interdisciplinary Bio Central},
Investigation of the genetic functions in complex biological systems is a challenging step in recent year. Hence, several valuable and interesting research projects have been developed with novel ideas to find out the unknown functions of genes or proteins. To validate the applicability of their novel ideas, various approaches are built up. To date, the most promising and commonly used approach for discovering the target proteins from biological system using small molecule is well known a… 
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This review contains information concerning the most relevant principles of chemical genetics with special emphasis on the different genomic and proteomic approaches used in forward chemical genetics to identify the molecular targets of the bioactive compounds, the advantages and disadvantages of each and a detailed list of successful examples of molecular targets identified with these approaches.
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