Target-Driven Evolution of Scorpion Toxins

@inproceedings{Zhang2015TargetDrivenEO,
  title={Target-Driven Evolution of Scorpion Toxins},
  author={Shangfei Zhang and Bin Gao and Shunyi Zhu},
  booktitle={Scientific reports},
  year={2015}
}
It is long known that peptide neurotoxins derived from a diversity of venomous animals evolve by positive selection following gene duplication, yet a force that drives their adaptive evolution remains a mystery. By using maximum-likelihood models of codon substitution, we analyzed molecular adaptation in scorpion sodium channel toxins from a specific species and found ten positively selected sites, six of which are located at the core-domain of scorpion α-toxins, a region known to interact with… CONTINUE READING
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