Target DNA Structure Plays a Critical Role in RAG Transposition

@article{Posey2006TargetDS,
  title={Target DNA Structure Plays a Critical Role in RAG Transposition},
  author={Jennifer E Posey and Malgorzata J. Pytlos and Richard R. Sinden and David B Roth},
  journal={PLoS Biology},
  year={2006},
  volume={4},
  pages={1592 - 1594}
}
Antigen receptor gene rearrangements are initiated by the RAG1/2 protein complex, which recognizes specific DNA sequences termed RSS (recombination signal sequences). The RAG recombinase can also catalyze transposition: integration of a DNA segment bounded by RSS into an unrelated DNA target. For reasons that remain poorly understood, such events occur readily in vitro, but are rarely detected in vivo. Previous work showed that non-B DNA structures, particularly hairpins, stimulate… CONTINUE READING

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