Tardive dyskinesia and new antipsychotics

@article{Correll2008TardiveDA,
  title={Tardive dyskinesia and new antipsychotics},
  author={Christoph U. Correll and Eva M Schenk},
  journal={Current Opinion in Psychiatry},
  year={2008},
  volume={21},
  pages={151–156}
}
Purpose of review To provide an update on tardive dyskinesia rates in patients treated with first-generation or second-generation antipsychotics in studies published since the last systematic review in 2004. Recent findings Across 12 trials (n = 28 051, age 39.7 years, 59.7% male, 70.9% white, followed for 463 925 person-years), the annualized tardive dyskinesia incidence was 3.9% for second-generation antipsychotics and 5.5% for first-generation antipsychotics. Stratified by age, annual… Expand
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Tardive Dyskinesia and Tardive Dystonia With Second-Generation Antipsychotics in Non-Elderly Schizophrenic Patients Unexposed to First-Generation Antipsychotics: A Cross-Sectional and Retrospective Study
TLDR
It is indicated that more clinical attention and research efforts are needed regarding SGA-associated tardive movement syndromes, including a larger-scale prevalence assessment, after the first to indicate that a comorbid obsessive-compulsive syndrome might be an associated factor of tardives movement syndrome. Expand
Tardive dyskinesia from atypical antipsychotic agents in patients with mood disorders in a clinical setting.
TLDR
The observed rate of tardive dyskinesia represents a real world estimate of the risk of TD with atypical antipsychotic agents in patients with mood disorders, and with early recognition symptoms appear to be reversible and further treatment with another atypicals does not necessarily lead to relapse. Expand
Tardive dyskinesia and other movement disorders secondary to aripiprazole
The objective of this report is to draw attention to tardive dyskinesia (TD) caused by aripiprazole, a third generation antipsychotic. TD has been traditionally attributed to typical… Expand
Covert Dyskinesia With Aripiprazole
TLDR
Litigation to date suggests that APZ is the atypical antipsychotic most commonly reported with CD, and a possible risk might be APZ's unique mechanism of action and its association with akathisia. Expand
Prevalence of tardive dyskinesia in chronic male inpatients with schizophrenia on long-term clozapine versus typical antipsychotics
TLDR
There are significant differences in the prevalence and clinical correlates of tardive dyskinesia in schizophrenia treated with clozapine versus typical antipsychotics. Expand
Tardive and spontaneous dyskinesia incidence in the general population
TLDR
Diabetes, psychoses, and especially schizophrenia are positively associated with SD and TD, with persons with schizophrenia having 4.4 times greater risk of SD than those without the disease. Expand
Pharmacotherapy for the treatment of tardive dyskinesia in schizophrenia patients
TLDR
This review will discuss the evidence for a number of medications of several different classes that have been studied for the treatment of TD since the 1970s with an emphasis on placebo controlled trials when possible and suggest the use of atypical versus conventional antipsychotics whenever possible. Expand
[Tardive dyskinesia in patients with schizophrenia treated with olanzapine - results from a 20-month, prospective, open study under naturalistic conditions].
TLDR
The study demonstrated high prevalence of tardive dyskinesia, and the annual incidence comparable to the results of a meta-analysis by Corell et al., and the use of antipsychotics in polytherapy more than tripled the risk of tARDive dysKinesia. Expand
Tardive Dyskinesia: Treatment Update
Tardive dyskinesia (TD) is caused by exposure to medications with dopamine antagonism, mainly antipsychotics. It often distresses individuals, physically and emotionally and affects their quality of… Expand
Clinical risk factors for the development of tardive dyskinesia
TLDR
Clinicians using dopamine antagonists need to consider risk factors for TD to minimize TD and its consequences. Expand
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