Tardive dyskinesia and atypical antipsychotic drugs

@article{Casey1999TardiveDA,
  title={Tardive dyskinesia and atypical antipsychotic drugs},
  author={Daniel E. Casey},
  journal={Schizophrenia Research},
  year={1999},
  volume={35},
  pages={S61-S66}
}
  • D. Casey
  • Published 1 March 1999
  • Psychology, Medicine
  • Schizophrenia Research

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The use of atypical antipsychotics as first line therapy for the treatment of schizophrenia is based largely on their reduced risk of EPS compared with conventional antipsychotic medications, Nevertheless, EPS with these drugs can occur, particularly when prescribed at high doses.

Untitled Page

TLDR
Frequent monitoring, while noting a patient’s subjective experience, remains the best strategy for choosing therapy to maximize symptom relief and minimize the impact of EPS and other side effects over the longterm.

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  • Psychology, Medicine
    Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
  • 2011
TLDR
Aripiprazole has a unique mechanism of action and has various effects in tardive dyskinesia, and the drug acts as a partial D2 receptor agonist that can stabilize D2 up-regulation and a 5-HT2A receptor antagonist that can increase the release of dopamine in the striatum.

Implications of the CATIE Trial on Treatment: Extrapyramidal Symptoms

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  • Psychology, Medicine
    CNS Spectrums
  • 2006
TLDR
The reported results of the CATIE trial regarding EPS are explored and the differentiation of the atypicals from perphenazine on EPS is emphasized and how these results should be incorporated into daily practice for the clinician is emphasized.

Historical perspectives on tardive dyskinesia

Gamma-aminobutyric acid agonists for antipsychotic-induced tardive dyskinesia.

TLDR
Data from six trials showed that there may be a clinically important improvement in TD symptoms after GABA agonist treatment compared with placebo at six to eight weeks follow-up, and the risk of bias in the included studies was unclear.

Investigating a novel antioxidant approach to the treatment of tardive dyskinesia

TLDR
The purpose of the current study was to establish a valid animal model of TD, followed by the evaluation of the behavioural and neurochemical effects of chronic NAC administration at various doses in a nonpathological state, i.e. in healthy rats.
...

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The amount of purposeless trunk and limb movement present proved to be a relatively stable phenomenon, showing only a slight increase with age and no change over the follow-up period.

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TLDR
Risperidone at 6 mg/day had the most beneficial effect on TD, especially on the BLM syndrome, without inducing significant parkinsonism while treating psychotic symptoms, and was greater than with either placebo or haloperidol.