Tardive dyskinesia, dopamine receptors, and neuroleptic damage to cell membranes.

  title={Tardive dyskinesia, dopamine receptors, and neuroleptic damage to cell membranes.},
  author={Philip Seeman},
  journal={Journal of clinical psychopharmacology},
  volume={8 4 Suppl},
  • Philip Seeman
  • Published 1988 in Journal of clinical psychopharmacology
The long-term treatment of schizophrenic patients with neuroleptics is associated with neuroleptic accumulation in neuromelanin-containing cells with ensuing nigral cell damage. Thus, in addition to early or short-term up-regulation of D2 dopamine receptors, the late stage denervation supersensitivity may result in a further proliferation of D2 dopamine receptors in those parts of the human striatum controlling mouth-lips-tongue motion. Young individuals, upon reduction or removal of the… CONTINUE READING

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