Tarantula Toxins Interact with Voltage Sensors within Lipid Membranes

  title={Tarantula Toxins Interact with Voltage Sensors within Lipid Membranes},
  author={Mirela Milescu and Jan Vobecky and Soung Hun Roh and Sung Hyun Kim and Hoi Jong Jung and Jae Il Kim and Kenton Jon Swartz},
  journal={The Journal of General Physiology},
  pages={497 - 511}
Voltage-activated ion channels are essential for electrical signaling, yet the mechanism of voltage sensing remains under intense investigation. The voltage-sensor paddle is a crucial structural motif in voltage-activated potassium (K(v)) channels that has been proposed to move at the protein-lipid interface in response to changes in membrane voltage. Here we explore whether tarantula toxins like hanatoxin and SGTx1 inhibit K(v) channels by interacting with paddle motifs within the membrane. We… CONTINUE READING
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