Tapping a bacterial enzymatic pathway for the preparation and manipulation of synthetic nanomaterials.

Abstract

We present a spherical micelle generated in a three-step sequence in which a farnesyl-pantetheine conjugate is phosphorylated, adenylated, and phosphorylated once more to generate a farnesyl-CoA amphiphile that self-assembles into spherical micelles. A sphere-to-fibril morphological switch is achieved by enzymatically transferring the farnesyl group of the… (More)
DOI: 10.1021/ja509827s

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