Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1α) docking protein

@inproceedings{Ferrar2012TaperinA,
  title={Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1α) docking protein},
  author={Tony S. Ferrar and Delphine Chamousset and Veerle De Wever and Mhairi Nimick and Jens Andersen and Laura Trinkle-Mulcahy and Greg B. G. Moorhead},
  booktitle={Biology open},
  year={2012}
}
The promiscuous activity of protein phosphatase one (PP1) is controlled in the cell by associated proteins termed regulatory or targeting subunits. Using biochemical and proteomic approaches we demonstrate that the autosomal recessive nonsyndromic hearing loss gene, taperin (C9orf75), encodes a protein that preferentially docks the alpha isoform of PP1… CONTINUE READING