Tapered progesterone withdrawal enhances behavioral and molecular recovery after traumatic brain injury

@article{Cutler2005TaperedPW,
  title={Tapered progesterone withdrawal enhances behavioral and molecular recovery after traumatic brain injury},
  author={Sarah Melissa Cutler and Edward H. Pettus and Stuart W. Hoffman and Donald G. Stein},
  journal={Experimental Neurology},
  year={2005},
  volume={195},
  pages={423-429}
}
Systemic injections of the neurosteroid progesterone improve cognitive recovery after traumatic brain injury (TBI) and stroke, and decrease molecular indicators of neuronal damage. Suddenly withdrawing progesterone after repeated dosing (PW) exacerbates ischemia and causes increased anxiety, seizure susceptibility, and excitotoxicity. Adult male Sprague-Dawley rats received either bilateral medial frontal cortex contusions or sham surgery. Injections were administered at 1 and 6 h post-injury… Expand
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TLDR
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