Tanshinone inhibits neuronal cell apoptosis and inflammatory response in cerebral infarction rat model

@inproceedings{Zhou2017TanshinoneIN,
  title={Tanshinone inhibits neuronal cell apoptosis and inflammatory response in cerebral infarction rat model},
  author={Liang Zhou and Jie Zhang and Chao Wang and Qiangsan Sun},
  booktitle={International journal of immunopathology and pharmacology},
  year={2017}
}
We aimed to investigate the effect and mechanisms of tanshinone (TSN) IIA in cerebral infarction. The cerebral infarction rat model was established by middle cerebral artery occlusion (MCAO). After pretreatment with TSN, cerebral infarct volume, cerebral edema, and neurological deficits score were evaluated, as well as cell apoptosis in hippocampus and cortex of the brain was examined with terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and the levels of interleukin-6 (IL-6… CONTINUE READING
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