Tanshinone IIA protects neonatal rat cardiomyocytes from adriamycin-induced apoptosis.

@article{Gao2008TanshinoneIP,
  title={Tanshinone IIA protects neonatal rat cardiomyocytes from adriamycin-induced apoptosis.},
  author={Jie Gao and Guoqing Yang and Rongbiao Pi and Ruifang Li and Ping Wang and Huijie Zhang and Kang Chian Le and Shao-rui Chen and Peiqing Liu},
  journal={Translational research : the journal of laboratory and clinical medicine},
  year={2008},
  volume={151 2},
  pages={79-87}
}
Tanshinone IIA (TSN) is a monomer extracted from the Chinese herb Danshen. In this study, we examined the effect of Tanshinone IIA on adriamycin (ADR)-induced apoptosis in neonatal rat cardiomyocytes and underlying molecular mechanisms. Primary cultured cardiomyocytes were treated with 1 micromol/L of adriamycin for 24 h with or without pretreatment with Tanshinone IIA (0.5-2 micromol/L) for 2 h. 3-(4,5-dimethyl thiazol-2yl)-2,5-diphenyltetrazolium bromide (MTT) assay, Hoechst staining, and… CONTINUE READING

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