Tanshinone IIA pretreatment attenuates hepatic ischemia-reperfusion.

  title={Tanshinone IIA pretreatment attenuates hepatic ischemia-reperfusion.},
  author={Yan-yan Qi and Liang Xiao and Lu-ding Zhang and Sh Song and Yi Mei and Teng Chen and Jian-ming Tang and Fang Liu and Guoshan Ding and Yong-zhao Shi and Quanxing Wang},
  journal={Frontiers in bioscience},
Tanshinone IIA (Tan IIA), an active component derived from Salvia miltiorrhiza root, has been used to treat various ischemic cardiovascular and cerebrovascular diseases. However, its impact on hepatic ischemia/reperfusion (I/R) injury remains unclear. Here, we addressed this issue by using a 90-minute partial liver ischemia model. Mice were administered Tan IIA intragastrically for 3 days before ischemia and were assessed for liver damage 6-h after reperfusion. Tan IIA pretreatment… 

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