Tanshinone IIA inhibits metastasis after palliative resection of hepatocellular carcinoma and prolongs survival in part via vascular normalization

@inproceedings{Wang2012TanshinoneII,
  title={Tanshinone IIA inhibits metastasis after palliative resection of hepatocellular carcinoma and prolongs survival in part via vascular normalization},
  author={Wen Wang and Liang Liu and Hui-chuan Sun and Yan-Ling Fu and Hua-Xiang Xu and Z G Chai and Qiangbo Zhang and Lingqun Kong and Xiao-Dong Zhu and Lu Lu and Zheng-gang Ren and Zhao-you Tang},
  booktitle={Journal of hematology & oncology},
  year={2012}
}
BACKGROUND Promotion of endothelial normalization restores tumor oxygenation and obstructs tumor cells invasion, intravasation, and metastasis. We therefore investigated whether a vasoactive drug, tanshinone IIA, could inhibit metastasis by inducing vascular normalization after palliative resection (PR) of hepatocellular carcinoma (HCC). METHODS A liver orthotopic double-tumor xenograft model in nude mouse was established by implantation of HCCLM3 (high metastatic potential) and HepG2 tumor… CONTINUE READING
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