Tanshinone II-A inhibits low density lipoprotein oxidation in vitro.

  title={Tanshinone II-A inhibits low density lipoprotein oxidation in vitro.},
  author={Xinhua Niu and Kohji Ichimori and Xiang-Qun Yang and Yoshinori Hirota and K Hoshiai and Minying Li and Hiroe Nakazawa},
  journal={Free radical research},
  volume={33 3},
Tanshinone II-A (TSII-A) is a major component of Salvia miltorrhiza Bunge which has long been used for preventing and ameliorating anginal pain in China. However the effect of TSII-A on low density lipoprotein (LDL) oxidation has not been studied. The present study was performed to investigate the effects of TSII-A on LDL oxidation using four oxidizing systems, including copper-, peroxyl radical- and peroxynitrite-initiated and macrophage-mediated LDL oxidation. LDL oxidation was measured in… CONTINUE READING


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