Tanshinone I enhances learning and memory, and ameliorates memory impairment in mice via the extracellular signal-regulated kinase signalling pathway.

@article{Kim2009TanshinoneIE,
  title={Tanshinone I enhances learning and memory, and ameliorates memory impairment in mice via the extracellular signal-regulated kinase signalling pathway.},
  author={Dong Hyun Kim and Sunho Kim and Su jin Jeon and Kun Ho Son and Seungjoo Lee and Byung Hoon Yoon and Jae Hoon Cheong and Kwang Ho Ko and Jong Hoon Ryu},
  journal={British journal of pharmacology},
  year={2009},
  volume={158 4},
  pages={1131-42}
}
BACKGROUND AND PURPOSE The intracellular signalling kinase, extracellular signal-regulated kinase 1/2 (ERK1/2) is required for new memory formation, suggesting that control of ERK signalling might be a target for the treatment of cognitive dysfunction. Previously, we reported that tanshinone congeners have ameliorating effects on drug-induced memory impairment in mice. Here, we have investigated possible modes of action of tanshinone I on learning and memory, associated with ERK phosphorylation… CONTINUE READING
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