Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition.

@article{CassSelves2012TankyraseAT,
  title={Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition.},
  author={Matias Cas{\'a}s-Selves and Jihye Kim and Zhiyong Zhang and Barbara A. Helfrich and Dexiang Gao and Christopher C. Porter and Hannah A. Scarborough and Paul A. Bunn and Daniel K. C. Chan and Aik Choon Tan and James V Degregori},
  journal={Cancer research},
  year={2012},
  volume={72 16},
  pages={4154-64}
}
Lung cancer is the leading cause of death worldwide. Adenocarcinomas, the most common histologic subtype of non-small cell lung cancer (NSCLC), are frequently associated with activating mutations in the epidermal growth factor receptor (EGFR) gene. Although these patients often respond clinically to the EGFR tyrosine kinase inhibitors erlotinib and gefitinib, relapse inevitably occurs, suggesting the development of escape mechanisms that promote cell survival. Using a loss-of-function, whole… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
Adenocarcinomas , the most common histologic subtype of non - small cell lung cancer ( NSCLC ) , are frequently associated with activating mutations in the epidermal growth factor receptor ( EGFR ) gene .
Adenocarcinomas , the most common histologic subtype of non - small cell lung cancer ( NSCLC ) , are frequently associated with activating mutations in the epidermal growth factor receptor ( EGFR ) gene .
Adenocarcinomas , the most common histologic subtype of non - small cell lung cancer ( NSCLC ) , are frequently associated with activating mutations in the epidermal growth factor receptor ( EGFR ) gene .
Adenocarcinomas , the most common histologic subtype of non - small cell lung cancer ( NSCLC ) , are frequently associated with activating mutations in the epidermal growth factor receptor ( EGFR ) gene .
Adenocarcinomas , the most common histologic subtype of non - small cell lung cancer ( NSCLC ) , are frequently associated with activating mutations in the epidermal growth factor receptor ( EGFR ) gene .
Adenocarcinomas , the most common histologic subtype of non - small cell lung cancer ( NSCLC ) , are frequently associated with activating mutations in the epidermal growth factor receptor ( EGFR ) gene .
Adenocarcinomas , the most common histologic subtype of non - small cell lung cancer ( NSCLC ) , are frequently associated with activating mutations in the epidermal growth factor receptor ( EGFR ) gene .
Adenocarcinomas , the most common histologic subtype of non - small cell lung cancer ( NSCLC ) , are frequently associated with activating mutations in the epidermal growth factor receptor ( EGFR ) gene .
Adenocarcinomas , the most common histologic subtype of non - small cell lung cancer ( NSCLC ) , are frequently associated with activating mutations in the epidermal growth factor receptor ( EGFR ) gene .
Adenocarcinomas , the most common histologic subtype of non - small cell lung cancer ( NSCLC ) , are frequently associated with activating mutations in the epidermal growth factor receptor ( EGFR ) gene .
Adenocarcinomas , the most common histologic subtype of non - small cell lung cancer ( NSCLC ) , are frequently associated with activating mutations in the epidermal growth factor receptor ( EGFR ) gene .
Adenocarcinomas , the most common histologic subtype of non - small cell lung cancer ( NSCLC ) , are frequently associated with activating mutations in the epidermal growth factor receptor ( EGFR ) gene .
Adenocarcinomas , the most common histologic subtype of non - small cell lung cancer ( NSCLC ) , are frequently associated with activating mutations in the epidermal growth factor receptor ( EGFR ) gene .
Adenocarcinomas , the most common histologic subtype of non - small cell lung cancer ( NSCLC ) , are frequently associated with activating mutations in the epidermal growth factor receptor ( EGFR ) gene .
All Topics