Tankyrase Sterile α Motif Domain Polymerization Is Required for Its Role in Wnt Signaling.

@article{Riccio2016TankyraseS,
  title={Tankyrase Sterile α Motif Domain Polymerization Is Required for Its Role in Wnt Signaling.},
  author={Amanda A. Riccio and Michael M. McCauley and M F Langelier and John M. Pascal},
  journal={Structure},
  year={2016},
  volume={24 9},
  pages={1573-81}
}
Tankyrase-1 (TNKS1/PARP-5a) is a poly(ADP-ribose) polymerase (PARP) enzyme that regulates multiple cellular processes creating a poly(ADP-ribose) posttranslational modification that can lead to target protein turnover. TNKS1 thereby controls protein levels of key components of signaling pathways, including Axin1, the limiting component of the destruction complex in canonical Wnt signaling that degrades β-catenin to prevent its coactivator function in gene expression. There are limited molecular… CONTINUE READING