Tankyrase 2 poly(ADP-ribose) polymerase domain-deleted mice exhibit growth defects but have normal telomere length and capping.

@article{Hsiao2006Tankyrase2P,
  title={Tankyrase 2 poly(ADP-ribose) polymerase domain-deleted mice exhibit growth defects but have normal telomere length and capping.},
  author={Susan J Hsiao and Marc F. Poitras and Brandoch D. Cook and Yie Liu and Susan Taylor Smith},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 6},
  pages={
          2044-54
        }
}
Regulation of telomere length maintenance and capping are a critical cell functions in both normal and tumor cells. Tankyrase 2 (Tnks2) is a poly(ADP-ribose) polymerase (PARP) that has been shown to modify itself and TRF1, a telomere-binding protein. We show here by overexpression studies that tankyrase 2, like its closely related homolog tankyrase 1, can function as a positive regulator of telomere length in human cells, dependent on its catalytic PARP activity. To study the role of Tnks2 in… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 33 CITATIONS

Similar Papers

Loading similar papers…