Tankyrase, a poly(ADP-ribose) polymerase at human telomeres.

@article{Smith1998TankyraseAP,
  title={Tankyrase, a poly(ADP-ribose) polymerase at human telomeres.},
  author={Susan Smith and Izabela Giriat and Anja Schmitt and Titia de Lange},
  journal={Science},
  year={1998},
  volume={282 5393},
  pages={
          1484-7
        }
}
Tankyrase, a protein with homology to ankyrins and to the catalytic domain of poly(adenosine diphosphate-ribose) polymerase (PARP), was identified and localized to human telomeres. Tankyrase binds to the telomeric protein TRF1 (telomeric repeat binding factor-1), a negative regulator of telomere length maintenance. Like ankyrins, tankyrase contains 24 ankyrin repeats in a domain responsible for its interaction with TRF1. Recombinant tankyrase was found to have PARP activity in vitro, with both… CONTINUE READING

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