Tanibirumab (TTAC-0001): A fully human monoclonal antibody targets vascular endothelial growth factor receptor 2 (VEGFR-2)

  title={Tanibirumab (TTAC-0001): A fully human monoclonal antibody targets vascular endothelial growth factor receptor 2 (VEGFR-2)},
  author={S. Lee},
  journal={Archives of Pharmacal Research},
  • S. Lee
  • Published 2011
  • Medicine, Chemistry
  • Archives of Pharmacal Research
Vascular endothelial growth factor (VEGF) binds to its receptor (VEGFR) and stimulates angiogenesis, an important step in tumor growth and metastasis. Several anticancer therapies targeting VEGFR with small molecules and antibody have been currently studied in preclinical and clinical studies. This article provides a review of human monoclonal antibody tanibirumab (TTAC-0001), which specifically binds VEGFR-2 and is currently being developed in preclinical stage by PharmAbcine (Daejon, Korea). 
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Ramucirumab (IMC-1121B): Monoclonal Antibody Inhibition of Vascular Endothelial Growth Factor Receptor-2
Aflibercept (AVE0005): an alternative strategy for inhibiting tumour angiogenesis by vascular endothelial growth factors.
  • Q. Chu
  • Medicine
  • Expert opinion on biological therapy
  • 2009
Ramucirumab (IMC-1121B): a novel attack on angiogenesis.
VEGF-Trap: A VEGF blocker with potent antitumor effects
  • J. Holash, S. Davis, +16 authors J. Rudge
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2002
VEGF: an update on biological and therapeutic aspects.
  • N. Ferrara
  • Biology, Medicine
  • Current opinion in biotechnology
  • 2000
The Role of Vascular Endothelial Growth Factor in Angiogenesis
Angiogenesis in cancer, vascular, rheumatoid and other disease
Angiogenesis as a therapeutic target
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis.
  • D. Hicklin, L. Ellis
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2005