Tango7 directs cellular remodeling by the Drosophila apoptosome.

@article{DBrot2013Tango7DC,
  title={Tango7 directs cellular remodeling by the Drosophila apoptosome.},
  author={Alejandro D'Brot and Po Guang Chen and Mahesh Vaishnav and Shujun Yuan and Christopher W Akey and John M. Abrams},
  journal={Genes & development},
  year={2013},
  volume={27 15},
  pages={1650-5}
}
It is now well appreciated that the apoptosome, which governs caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells. However, the determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. Here we report that Tango7 collaborates with the Drosophila apoptosome to drive a caspase-dependent remodeling process needed to resolve individual sperm from a syncytium. In these cells, Tango7 is required for caspase activity and… CONTINUE READING
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