Tangled bank of experimentally evolved Burkholderia biofilms reflects selection during chronic infections.

@article{Traverse2013TangledBO,
  title={Tangled bank of experimentally evolved Burkholderia biofilms reflects selection during chronic infections.},
  author={Charles C. Traverse and Leslie M. Mayo-Smith and Steffen R Poltak and Vaughn S. Cooper},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 3},
  pages={E250-9}
}
How diversity evolves and persists in biofilms is essential for understanding much of microbial life, including the uncertain dynamics of chronic infections. We developed a biofilm model enabling long-term selection for daily adherence to and dispersal from a plastic bead in a test tube. Focusing on a pathogen of the cystic fibrosis lung, Burkholderia cenocepacia, we sequenced clones and metagenomes to unravel the mutations and evolutionary forces responsible for adaptation and diversification… CONTINUE READING
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