Tangier disease as a test of the reverse cholesterol transport hypothesis.

@article{Tall2000TangierDA,
  title={Tangier disease as a test of the reverse cholesterol transport hypothesis.},
  author={Alan Richard Tall and Nan Wang},
  journal={The Journal of clinical investigation},
  year={2000},
  volume={106 10},
  pages={1205-7}
}
Atherosclerotic cardiovascular disease is the major killer in industrialized societies. Treatment of this disorder via LDL lowering, particularly with statin drugs, has been partially effective but no panacea. Many patients developing coronary heart disease (CHD) do not have markedly elevated LDL but rather have low HDL levels, alone or accompanied by hypertriglyceridemia. The strong inverse relationship between HDL levels and atherosclerotic cardiovascular disease has been known for more than… CONTINUE READING
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High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1

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The correlation of ATP-binding cassette 1 mRNA levels with cholesterol efflux from various cell lines

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