Tandospirone and alprazolam: comparison of behavioral effects and abuse liability in humans.

@article{Evans1994TandospironeAA,
  title={Tandospirone and alprazolam: comparison of behavioral effects and abuse liability in humans.},
  author={S. M. Evans and J R Troisi and R R Griffiths},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1994},
  volume={271 2},
  pages={683-94}
}
Tandospirone is a novel nonbenzodiazepine anxiolytic/antidepressant that acts primarily at the serotonin-1A receptor. In the present study, the behavioral effects and abuse liability of tandospirone were characterized relative to those of the benzodiazepine, alprazolam. In an outpatient setting, the acute effects of placebo, tandospirone citrate (40, 80 and 160 mg) and alprazolam (0.5, 1.0 and 2.0 mg) were assessed with a double-blind, cross-over design in 14 male volunteers with histories of… CONTINUE READING