Tandem triad systems based on FRET for two-photon induced release of glutamate.

@article{Picard2013TandemTS,
  title={Tandem triad systems based on FRET for two-photon induced release of glutamate.},
  author={S{\'e}bastien D. Le Picard and Eduardo J. Cueto-D{\'i}az and Emilie G{\'e}nin and Guillaume Clermont and Francine C. Acher and David Ogden and Mireille Blanchard‐Desce},
  journal={Chemical communications},
  year={2013},
  volume={49 92},
  pages={
          10805-7
        }
}
Tandem systems allowing enhanced two-photon (2P) absorption in a wavelength range permitting coupling of the primary excitation by energy transfer to an intramolecular cage known to have fragmentation properties suited to photolysis in neuroscience is demonstrated to lead to a 10-fold improvement in the 2P photolysis cross-section at experimentally compatible wavelengths. 
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19 Citations

19 Citations

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Citation Type

Tandem Systems for Two-Photon Uncaging of Bioactive Molecules.
TLDR
This Minireview highlights this versatile strategy, with a discussion of different tandem 2P uncagers, relying on photoinduced electron transfer (PET), triplet-energy transfer (TT-ET), or Förster resonance energy transfer (FRET) sensitization to enhance the 2P sensitivity of PPGs.
Cooperative dyads for two-photon uncaging.
TLDR
A series of dyads that combine a photolabile protecting group (PPG) 4,5-dimethoxy-2-nitrobenzyl and different bis-donor or bis-acceptor dissymmetric chromophores acting as two-photon (2P) absorbers were synthesized and improvement of the 2P uncaging sensitivity in the NIR is achieved as compared to isolated PPG.
Cooperative porphyrin-quadrupolar based triad for combined two-photon induced fluorescence and singlet oxygen generation
The design and synthesis of a cooperative multichromophoric triad system which combines the large two-photon absorption properties of fluorene-cored bis-donor quadropolar dyes and the remarkable…
Pulse-shaping based two-photon FRET stoichiometry.
TLDR
Two-photon FRET stoichiometry is demonstrated in live COS-7 cells expressing fluorescent proteins mAmetrine as the donor and tdTomato as the acceptor using the generalized theory.
Photo-redox activated drug delivery systems operating under two photon excitation in the near-IR.
TLDR
A nano-container consisting of mesoporous silica nanoparticles with the pore openings covered by "snap-top" caps that are opened by near-IR light is constructed that may lead to a new type of photodynamic drug release therapy.
Caged glutamates with π-extended 1,2-dihydronaphthalene chromophore: design, synthesis, two-photon absorption property, and photochemical reactivity.
TLDR
The design, synthesis, and photochemical reactivity of caged glutamates with π-extended 1,2-dihydronaphthalene structures, which possess a two-photon cross-section of ∼120 GM and an excellent buffer solubility, are described.
Cooperative Veratryle and Nitroindoline Cages for Two-Photon Uncaging in the NIR.
TLDR
The interactions between the 2PA module and the caging moiety are found to promote cooperative effects on the2PA response while additional processes that enhance the uncaging efficiency are operative in well-oriented nitroindoline-derived dyads.
Quinoline-derived two-photon sensitive quadrupolar probes.
TLDR
The first quadrupolar 8-dimethylaminoquinoline-derived photosensitive probes underwent photolysis under UV and NIR irradiation conditions, showing Qu = 9.3% and 6.6% quantum yields and δu = 0.07 GM and 0.40 GM uncaging cross-sections, respectively.
Quinoline-Derived Two-Photon Sensitive Quadrupolar Probes.
TLDR
Quadrupolar probes derived from 8-dimethylamino-quinoline having a pegylated fluorene core were prepared and studied and Compound 1 a was identified as the most efficient probe by UV activation that showed sequential release of acetic acid as a model.
Dendrimer conjugation enables multiphoton chemical neurophysiology with an extended π-electron caging chromophore.
TLDR
It is expected that the cloaking method will enable the development of new classes of cell-compatible photolabile probes using a wide variety of extended π-electron caging chromophores, enabling high-resolution two-photon uncaging without any side effects.
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