Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer.

@article{Itoga2002TandemRP,
  title={Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer.},
  author={Sakae Itoga and Fumio Nomura and Yasuhiko Makino and Takeshi Tomonaga and Hideaki Shimada and Takenori Ochiai and Toshihiko Iizasa and M. Rajesh Baba and Takehiko Fujisawa and Shoji Harada},
  journal={Alcoholism, clinical and experimental research},
  year={2002},
  volume={26 8 Suppl},
  pages={15S-19S}
}
BACKGROUND Cytochrome P-450 (CYP) enzymes have been shown to play important roles in chemical carcinogenesis. Reports have indicated that polymorphism in CYP1A1, CYP1A2, CYP2A6, CYP2E1, and CYP2D6 are associated with an altered risk of developing cancers of the lung, bladder, liver, and colon. CYP2E1 plays an important role in alcohol metabolism and participates in the metabolic activation of various carcinogens, such as N-nitrosodimethylamine. Recently, we found repeated sequences that consist… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Human hepatic CYP2E1 expression during development.

The Journal of pharmacology and experimental therapeutics • 2003
View 6 Excerpts
Highly Influenced

Gene-environment interactions in esophageal cancer.

Critical reviews in clinical laboratory sciences • 2015

Similar Papers

Loading similar papers…