Tandem regulation of phosphoinositide signaling and acute behavioral effects induced by antidepressant agents in rats

@article{Tyeryar2007TandemRO,
  title={Tandem regulation of phosphoinositide signaling and acute behavioral effects induced by antidepressant agents in rats},
  author={Kimberly R. Tyeryar and Ashiwel S. Undie},
  journal={Psychopharmacology},
  year={2007},
  volume={193},
  pages={271-282}
}
Antidepressants increase synaptic monoamine concentrations, but the subsequent signaling events that produce the beneficial clinical effects remain unclear. Diverse antidepressants increase CDP-diacylglycerol, a crucial step in phosphoinositide signaling. Serotonin 5HT2 receptors, implicated in depression or the actions of some antidepressants, signal through phosphoinositide hydrolysis. Thus, cross talk between antidepressant-induced CDP-diacylglycerol and 5HT2 signaling could contribute to… CONTINUE READING

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