Tandem placement of a coronavirus promoter results in enhanced mRNA synthesis from the downstream-most initiation site.

@article{Krishnan1996TandemPO,
  title={Tandem placement of a coronavirus promoter results in enhanced mRNA synthesis from the downstream-most initiation site.},
  author={Rajesh Krishnan and Rong Chang and David A. Brian},
  journal={Virology},
  year={1996},
  volume={218 2},
  pages={400-5}
}
Insertion of the 17-nucleotide promoter region for the bovine coronavirus N gene as part of a 27-nucleotide cassette into the open reading frame of a cloned synthetic defective-interfering (DI) RNA resulted in synthesis of subDI RNA transcripts from the replicating DI RNA genome. Duplicating and triplicating the promoter sequence in tandem caused a progressive increase in the efficiency of subgenomic mRNA synthesis despite a concurrent decrease in the rate of DI RNA accumulation that was not… CONTINUE READING
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