Tandem mass spectrometric analysis of cyclophosphamide, ifosfamide and their metabolites.

@article{Liu2005TandemMS,
  title={Tandem mass spectrometric analysis of cyclophosphamide, ifosfamide and their metabolites.},
  author={Zhongfa Liu and Kenneth K Y Chan and Jeffrey J Wang},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2005},
  volume={19 18},
  pages={2581-90}
}
A detailed multi-stage (MSn) fragmentation study of cyclophosphamide (CP), ifosfamide (IF) and their major metabolites, using an ion-trap mass spectrometer and a Q-TOF mass spectrometer, was performed with the aid of specifically deuterium-labeled analogs. The analytes showed good responses in positive-ion electrospray mass spectrometry as [MH]+ ions. Tandem mass spectra revealed a wealth of structurally specific ions, allowing characterization of the fragmentation pathways of these analytes… CONTINUE READING