Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

Abstract

We have recently identified an internal tandem duplication of the human Flt3 gene in approximately 20% of acute myeloid leukemia (AML) cases. In the present study, the wild-type and the mutant Flt3 genes were transfected into two IL-3-dependent cell lines, 32D and BA/F3 cells. Mutant Flt3-transfected cells exhibited autonomous growth while wild-type Flt3… (More)
DOI: 10.1038/sj.onc.1203354

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@article{Hayakawa2000TandemduplicatedFC, title={Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines}, author={Fumihiko Hayakawa and Masayuki Towatari and Hitoshi Kiyoi and Mitsune Tanimoto and Toshio Kitamura and Hidehiko Saito and Tomoki Naoe}, journal={Oncogene}, year={2000}, volume={19}, pages={624-631} }