Tandem autologous stem cell transplantation in high-risk de novo multiple myeloma: final results of the prospective and randomized IFM 99-04 protocol.

@article{Moreau2006TandemAS,
  title={Tandem autologous stem cell transplantation in high-risk de novo multiple myeloma: final results of the prospective and randomized IFM 99-04 protocol.},
  author={Philippe Moreau and Cyrille Hullin and Fr{\'e}d{\'e}ric Garban and Ibrahim Yakoub-Agha and Lotfi Benboubker and Michel Attal and G{\'e}rald Marit and J. -G. Fuzibet and Chantal Doyen and Laurent Voillat and Christian Berthou and Nicolas Ketterer and Philippe Casassus and Mathieu Monconduit and Mauricette Michallet and A hamdi Najman and Jean-Jacques Sotto and R{\'e}gis Bataille and J. -L. Harousseau},
  journal={Blood},
  year={2006},
  volume={107 1},
  pages={397-403}
}
The combination of high levels of beta2-microglobulin (beta2-m) and chromosome 13 deletion allows identification of a high-risk subgroup of patients with de novo multiple myeloma (MM). In this population of patients, we have evaluated the impact of a murine anti-interleukin 6 (anti-IL-6) monoclonal antibody (BE-8) as part of the second conditioning regimen in a multicenter prospective randomized trial of tandem autologous stem cell transplantation (ASCT). Conditioning for the first ASCT was… CONTINUE READING
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