Tandem array–based expression screens identify host mRNA targets of virus-encoded microRNAs

@article{Ziegelbauer2009TandemAE,
  title={Tandem array–based expression screens identify host mRNA targets of virus-encoded microRNAs},
  author={Joseph M Ziegelbauer and Christopher S. Sullivan and Don Ganem},
  journal={Nature Genetics},
  year={2009},
  volume={41},
  pages={130-134}
}
MicroRNAs (miRNAs) are short noncoding RNAs of cellular and viral origin that post-transcriptionally regulate gene expression through imperfect base pairing to their mRNA targets. Because the recognition sequences of miRNAs for their targets are short and may be discontinuous, bioinformatic prediction of targets is difficult. Here we present an approach to the experimental identification of the mRNA targets of miRNAs encoded by the Kaposi's sarcoma–associated herpesvirus (KSHV). KSHV encodes 17… CONTINUE READING
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