Tandem application of flow cytometry and polymerase chain reaction for comprehensive detection of minimal residual disease in childhood acute lymphoblastic leukemia

@article{Neale1999TandemAO,
  title={Tandem application of flow cytometry and polymerase chain reaction for comprehensive detection of minimal residual disease in childhood acute lymphoblastic leukemia},
  author={G A M Neale and Elaine Coustan-Smith and Qiulu Pan and X Chen and Bernd Gruhn and Patricia Stow and F L Behm and C -H Pui and Dario Campana},
  journal={Leukemia},
  year={1999},
  volume={13},
  pages={1221-1226}
}
Children with acute lymphoblastic leukemia (ALL) with 0.01% leukemic cells in the bone marrow after remission induction are at a greater risk of relapse. The most promising methods of detecting minimal residual disease (MRD) are flow cytometric identification of leukemia-associated immunophenotypes and polymerase chain reaction (PCR) amplification of antigen-receptor genes. However, neither assay can be applied to all patients. Moreover, both assays carry the risk of false-negative findings due… CONTINUE READING
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