Tandem-Pore K+ Channels Mediate Inhibition of Orexin Neurons by Glucose

@article{Burdakov2006TandemPoreKC,
  title={Tandem-Pore K+ Channels Mediate Inhibition of Orexin Neurons by Glucose},
  author={Denis Burdakov and Lise Torp Jensen and Haris Alexopoulos and Rh{\^i}annan H. Williams and Ian M. Fearon and Ita O'kelly and Oleg V Gerasimenko and Lars Fugger and Alexei Verkhratsky},
  journal={Neuron},
  year={2006},
  volume={50},
  pages={711-722}
}
Glucose-inhibited neurons orchestrate behavior and metabolism according to body energy levels, but how glucose inhibits these cells is unknown. We studied glucose inhibition of orexin/hypocretin neurons, which promote wakefulness (their loss causes narcolepsy) and also regulate metabolism and reward. Here we demonstrate that their inhibition by glucose is mediated by ion channels not previously implicated in central or peripheral glucose sensing: tandem-pore K(+) (K(2P)) channels. Importantly… CONTINUE READING
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