Tandem Fusion of Hepatitis B Core Antigen Allows Assembly of Virus-Like Particles in Bacteria and Plants with Enhanced Capacity to Accommodate Foreign Proteins

@inproceedings{Peyret2015TandemFO,
  title={Tandem Fusion of Hepatitis B Core Antigen Allows Assembly of Virus-Like Particles in Bacteria and Plants with Enhanced Capacity to Accommodate Foreign Proteins},
  author={Hadrien Peyret and Annick Gehin and Eva C. Thuenemann and Donatienne Blond and Aadil El Turabi and Lucy Beales and Dean Clarke and Robert J C Gilbert and Elizabeth E. Fry and David I Stuart and Kris Holmes and Nicola J Stonehouse and Mike Whelan and William Rosenberg and G. P. Lomonossoff and David J Rowlands},
  booktitle={PloS one},
  year={2015}
}
The core protein of the hepatitis B virus, HBcAg, assembles into highly immunogenic virus-like particles (HBc VLPs) when expressed in a variety of heterologous systems. Specifically, the major insertion region (MIR) on the HBcAg protein allows the insertion of foreign sequences, which are then exposed on the tips of surface spike structures on the outside of the assembled particle. Here, we present a novel strategy which aids the display of whole proteins on the surface of HBc particles. This… CONTINUE READING
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