Tandem DNA recognition by PhoB, a two-component signal transduction transcriptional activator.

@article{Blanco2002TandemDR,
  title={Tandem DNA recognition by PhoB, a two-component signal transduction transcriptional activator.},
  author={Alexandre G. Blanco and Mar{\'i}a del Mar Sola and F Xavier Gomis-R{\"u}th and M. Dolores Coll},
  journal={Structure},
  year={2002},
  volume={10 5},
  pages={701-13}
}
PhoB is a signal transduction response regulator that activates nearly 40 genes in phosphate depletion conditions in E. coli and closely related bacteria. The structure of the PhoB effector domain in complex with its target DNA sequence, or pho box, reveals a novel tandem arrangement in which several monomers bind head to tail to successive 11-base pair direct-repeat sequences, coating one face of a smoothly bent double helix. The protein has a winged helix fold in which the DNA recognition… CONTINUE READING
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