Tamsulosin: an update of its role in the management of lower urinary tract symptoms.

@article{LysengWilliamson2002TamsulosinAU,
  title={Tamsulosin: an update of its role in the management of lower urinary tract symptoms.},
  author={Katherine A Lyseng-Williamson and Blair Jarvis and Antona J. Wagstaff},
  journal={Drugs},
  year={2002},
  volume={62 1},
  pages={135-67}
}
UNLABELLED Tamsulosin is a selective alpha1A- and alpha1D-adrenoceptor antagonist. These alpha1-receptors are predominant in the prostate, prostatic capsule, prostatic urethra and bladder. The relaxation of prostate and bladder smooth muscles may result in improvement in maximum urine flow (Qmax) and reduction of lower urinary tract symptoms (LUTS). Tamsulosin 0.4 and 0.8 mg/day in a modified-release formulation was significantly more effective than placebo in large (n >250) double-blind… CONTINUE READING