Tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist. A meta-analysis of two randomized, placebo-controlled, multicentre studies in patients with benign prostatic obstruction (symptomatic BPH). European Tamsulosin Study Group.

@article{Chapple1996TamsulosinTF,
  title={Tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist. A meta-analysis of two randomized, placebo-controlled, multicentre studies in patients with benign prostatic obstruction (symptomatic BPH). European Tamsulosin Study Group.},
  author={Christopher R Chapple and Jean-Jacques Wyndaele and Jorgen Nordling and Frank Boeminghaus and A F G V M Ypma and Paul G. Abrams},
  journal={European urology},
  year={1996},
  volume={29 2},
  pages={155-67}
}
OBJECTIVE This meta-analysis of two European studies evaluated the efficacy and safety of modified-release tamsulosin 0.4 mg once daily compared with placebo in patients with benign prostatic enlargement, lower urinary tract symptoms and prostatic obstruction (symptomatic BPH). METHODS Patients entered a 2-week placebo run-in period, followed by randomization to treatment with tamsulosin (382 patients) or placebo (193 patients) once daily for 12 weeks. RESULTS Maximum urinary flow rate… CONTINUE READING
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