Tamoxifen treats symptoms of mania in patients with bipolar disorder

The protein kinase C (PKC) signaling cascade has been identified as a direct biochemical target for the treatment of mania. Preclinical studies and early clinical trials have shown that the anticancer agent tamoxifen, a relatively selective PKC inhibitor that can cross the blood–brain barrier, exerts an antimanic effect in a mouse model of mania. Zarate et… CONTINUE READING