Tamoxifen therapy for the management of pubertal gynecomastia: a systematic review

@inproceedings{Lapid2013TamoxifenTF,
  title={Tamoxifen therapy for the management of pubertal gynecomastia: a systematic review},
  author={O. Lapid and J. J. van Wingerden and L. Perlemuter},
  booktitle={Journal of pediatric endocrinology \& metabolism : JPEM},
  year={2013}
}
Abstract Objective: A systematic review to assess the efficacy of tamoxifen in the management of idiopathic pubertal gynecomastia. Data sources: Searches were conducted using the databases of Medline (search engine PubMed) and Web of Science®. Study selection: Studies reporting the use of Tamoxifen for the treatment of gynecomastia in adolescents. Outcome measure: Resolution of gynecomastia. Results: A total of 164 publications were found; 59 were selected for retrieval and six were included in… Expand
Tamoxifen to treat male pubertal gynaecomastia
  • A. Zehetner
  • Medicine
  • International journal of pediatrics & adolescent medicine
  • 2015
TLDR
Tamoxifen, a selective oestrogen receptor modulator (SERM), given at 20 mg daily for six months, was found to be a safe, well-tolerated and effective alternative treatment to current therapeutic options of watchful waiting (no management) and invasive cosmetic surgery. Expand
Pubertal gynecomastia: years of progress – the Hacettepe experience
TLDR
The ‘Hacettepe indications for tamoxifen treatment for pubertal gynecomastia’ will aid physicians when considering treating these patients, and are presented as a conclusion to all the studies performed. Expand
Management of adolescent gynecomastia: an update
TLDR
It appears that pharmacological therapy of persistent adolescent gynecomastia is reasonable effective if given early in the course of the disease and more successful in cases with small or moderate breast enlargement. Expand
Oestrogen and progesterone receptors in bilateral and unilateral pubertal gynecomastia – is treatment with anti-oestrogens justified?
TLDR
Oestrogen and progesterone receptors may play a role in the aetiology of PG, especially in bilateral cases, and are a starting point for studies on differences between unilateral and bilateral PG. Expand
Surgical treatment of primary gynecomastia in children and adolescents
TLDR
In comparing both surgical techniques, combination of mastectomy and liposuction revealed better results in every measure except for surgical duration (median 73 vs 90 min); in contrast to adults, skin in children and adolescents provides high retractability, therefore, open reduction combined with minimally invasive Liposuction was proven useful. Expand
The effect of tamoxifen on pubertal bone development in adolescents with pubertal gynecomastia
TLDR
Assessment of the effects of tamoxifen on bone mineral density (BMD) and skeletal maturation when used for pubertal gynecomastia concluded that when Pubertal bone development is concerned, tamoxIFen is safe for the treatment of pubertals gyne comastia as neither bone mineralization nor growth potential was affected. Expand
Ginecomastia: aspectos generales y etiológicos
TLDR
The aim of this article is to discuss some key points about the most important aspects related to gynecomastia, including pathophysiology, symptoms, and diagnosis, in addition to presenting the main causes associated with this condition. Expand
Childhood Gynecomastia: A Mini Review
TLDR
The pathophysiology, etiology, diagnosis and various medical and surgical therapies ofynecomastia will be highlighted. Expand
Gynaecomastia—pathophysiology, diagnosis and treatment
TLDR
Gynaecomastia (enlargement of the male breast tissue) is a common finding in the general population, and administration of androgens might be helpful, as might antiestrogen therapy in men with endogenous overproduction of estrogens. Expand
Ginecomastia fisiológica puberal
Gynecomastia may be a normal variant of the pubertal development observed in male teenagers and, although there are no abundant statistical data on its prevalence, a significant number of patientsExpand
...
1
2
3
...

References

SHOWING 1-10 OF 26 REFERENCES
Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia.
TLDR
Inhibition of estrogen receptor action in the breast appears to be safe and effective in reducing persistent pubertal gynecomastia, with a better response to raloxifene than to tamoxifen. Expand
Tamoxifen treatment for pubertal gynecomastia
TLDR
Tamoxifen treatment is relatively non-toxic, may be beneficial and it should be considered for pubertal gynecomastia, and the dose was increased in three patients due to poor response. Expand
[Treatment of marked gynecomastia in puberty with tamoxifen].
TLDR
The reduction of breast size in spite of increased estradiol levels on the other hand, suggests that the mean therapeutic effect of tamoxifen is through estrogen receptor blockade of breast tissue. Expand
Tamoxifen for the management of breast events induced by non-steroidal antiandrogens in patients with prostate cancer: a systematic review
TLDR
The currently available evidence suggests good efficacy of tamoxifen for the prevention and treatment of breast events induced by non-steroidal antiandrogens in prostate cancer patients. Expand
Gynecomastia in adolescents
TLDR
During adolescence, male breast enlargement is most often benign and rarely represents a pathologic mechanism, and reassurance remains the standard of care for physiologic gynecomastia. Expand
Prevention of gynecomastia and breast pain caused by androgen deprivation therapy in prostate cancer: tamoxifen or radiotherapy?
TLDR
Although TMX was two times more effective in preventing gynecomastia, RT should represent an effective and safe treatment option, to take into account mainly in patients with cardiovascular risk factors or thrombotic diathesis. Expand
Long-term Follow-up of Tamoxifen Treatment in Adolescents with Gynecomastia
Ten pubertal boys treated with tamoxifen for gynecomastia for more than 3 months were evaluated after 2.5-7 years (mean 4.6 years) to determine the side effects of this therapy. We assessed theExpand
The Effect of Tamoxifen on Sex Hormone Binding Globulin in Adolescents with Pubertal Gynecomastia
TLDR
The relationship between sex hormone binding globulin (SHBG) and pubertal gynecomastia in 21 adolescents evaluated longitudinally is investigated and it is suggested that serum SHBG is increased by tamoxifen treatment in male adolescents. Expand
Gynecomastia in adolescent boys.
TLDR
It is recommended that adolescent gynecomastia should not be treated either surgically or with hormones, but that the boy and his parents should be assured that this is a normal phenomenon of puberty which will disappear within 1 or 2 years. Expand
Evaluation and treatment of gynecomastia.
TLDR
A thorough history, a complete physical examination and an appropriate clinical evaluation facilitate the prompt diagnosis and treatment of gynecomastia. Expand
...
1
2
3
...